VEGF-A/NRP1 STIMULATES GIPC1 AND SYX COMPLEX FORMATION TO PROMOTE RHOA ACTIVATION AND PROLIFERATION IN SKIN CANCER CELLS

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor.DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1.In the present study, the RNA interference of VEGF-A or NRP1 suppressed DJM-1 cell proliferation.Furthermore, the overexpression of the NRP1 wild type restored shNRP1-treated DJM-1 cell proliferation, whereas NRP1

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Peran Akal Menurut Pandangan Al-Ghazali

Intellect is a tool of thought contained in human beings, the human mind is different from other creatures because sense is given only in humans and is not given to other creatures.This difference has made humans superior and smarter in managing their lives.Therefore man with a clear intellect would find God as the final returns from real life.Acco

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